CCOHS is a corporation under Schedule II of the Financial Administration Act. Its policies are established by the Council of Governors, which consists of a Chairman and 12 representatives from labour, employers' organizations, and the federal, provincial and territorial governments. It meets three times a year. The Chairman is appointed by federal Order‑in‑Council. The President and Chief Executive Officer supervises and directs the work and staff of the Centre.

There are seven departments through which the program is delivered.

Corporate Management
Provides the direction and management of operations at CCOHS and also includes Human Resources.

General Health and Safety Services
Provides occupational health and safety products and services to business, labour organizations, governments, media and health and safety professionals.

Finance
The finance department is responsible for accounting, finance, government reporting, internal systems (computer network) and facilities managements.

Training and Education Services
Provides training on various occupational health and safety through class room course, e-learning, presentations and various publications.

Chemical Services
Provides occupational health and safety information and products focusing on chemicals in the workplace.

Inquiries and Customer Service
Responds directly to occupational health and safety inquiries from the public. Also provides support for sales and technical assistance to customers who purchase CCOHS products.

Communications
Provides the promotion, marketing and communication services for CCOHS public services and cost recovery products.